One of the few female French comic artists, Annie Goetzinger began making comics by accident, because her art school wouldn't let her pass without making a comic. Since then, she has been publishing various comics, and contributed to the magazines Pilote, Charlie Mensuel and Fluide Glacial. Her work can be recognized by her Art Nouveau-influenced style. Most of her stories have a feminine point of view, and have been published in book format by Hachette, Glénat, Dargaud and Éditions des Femmes.
Goetzinger's earliest work appeared in Pilote in the early 1970s; mainly short stories with scripts by Jean-Pierre Dionnet, Jacques Lob and Truchaud. She was also present in Lisette with 'Fleur', in Le Canard Sauvage, and in Circus with 'Casque d'Or'. In 1978, she created 'Félina', her first major comic story, with Victor Mora in Circus. The series was later continued in Pilote and Charlie Mensuel. By this time, Goetzinger also contributed to magazines like Fluide Glacial and L'Écho des Savanes.
Also in 1978, she made 'Aurore', a comics version of the life of George Sand, published by Éditions Des Femmes. With scriptwriter Pierre Christin, she made a series of "portraits souvenirs", including 'La Demoiselle à la Legion d'Honneur', 'La Diva et le Krigspiel', 'La Voyageuse de la Petite Ceinture' and 'Charlotte et Nancy', published by Dargaud and later Les Humanoïdes Associés. Also for Les Humanoïdes, she wrote and drew 'Barcelonight' in 1991, and cooperated with Jon S. Jonsson and Andreas Knigge on 'L'Avenir Perdu' in 1992.
In addition, she cooperated with Christin on 'Le Tango du Disparu' (Flammarion, 1989), 'Le Message du Simple' (Ed. du Seuil, 1994), 'La Sultane Blanche' and 'Paquebot' (in the collection Long Courrier of Dargaud, 1996 and 1999). With Montserrat Roig, she made 'Mémoires de Barcelone' at Ed. La Sirène in 1993. Goetzinger and Christin then started the retro 1950s series 'L'Agence Hardy', that is published by Dargaud since 2001. Her chronicle 'L'Humeur des Jours', written by Bruno Frappat, appeared in La Croix for several years, and was collected in the book 'Le Regard des Jours' by Dargaud in 2005. In 2011 she cooperated with Rodolphe on 'Marie-Antoinette, la Reine fantôme'.