Ed Leffingwell started his comics career assisting his cousin Harold Gray on 'Little Orphan Annie'. Aided by Gray, he developed his own Sunday strip, launched under the title 'Little Joe' (1933) through the Chicago Tribune Syndicate. Leffingwell's strip, about a teenager on a cattle ranch, was also known as 'Little Joe & Ze General'. When Ed Leffingwell died in 1936, the strip was taken over by his brother Robert, who continued it until 1972.