Carlos Meglia debuted in 1974 as the assistant of the illustrator Oswal. Two years later, he made science-fiction illustrations for El Pendula, as well as covers for Record publishers. In 1979 Meglia illustated 'La Bible pour les Enfants', 'Don Quichotte' and several books of the poet Martin Fierro. In the early 1980s, he contributed to Billiken, a children's magazine, Satiricon, a humorous periodical and El Grafico, a sports magazine.
In 1983, Meglia made his first short comic stories for publisher Record, and in the three years that followed, he worked mainly in the animation field (a.o. on 'The Smurfs', 'The Flintstones' and 'Scooby Doo'). He teamed up with Carlos Trillo in 1987, and started 'Irish Coffee', a series about a detective with supernatural gifts. Also with Trillo, Meglia launched the 'Cybersix' series in 1991, a series in which he intensively uses the computer. In the second half of the 1990s, he settled in Spain and began working for the US market. He cooperated on Dark Horse titles like 'Star Wars: Underworld' and 'Spyboy', as well as DC's 'Superman/Tarzan: Sons of the Jungle', 'Crimson', 'Adventures of Superman' and 'Monster World', and Marvel's 'Elektra'. In 2005, he created the series 'Canari' with Crisse. Carlos Meglia passed away, at the top of his game, on 15 August 2008 at the age of 50.