Born in Paris, Ralph Meyer moved to Liège to study at the Saint-Luc Institute. He made his debut comic with the series 'Berceuse Assassine' in cooperation with scriptwriter Tome at Dargaud between 1997 and 2002. He joined Tome and Bruno Gazzotti in the atelier P.J.A.D. and worked with Gazzotti and Vehlmann on several short stories for Spirou, as well as 'Des Lendemains sans Nuage' in the collection Signé of Lombard.
Also with Vehlmann, he began the futuristic series 'IAN' for Dargaud in 2003. In 2008 he drew the first installment in the collection 'XIII Mystery', focusing on the Mongoose, that was written by Xavier Dorison. In 2010 he made the oneshot 'Page Noire' with Frank Giroud and Denis Lapière for Futuropolis. He has worked with Dorison again on the series 'Asgard', that was published by Dargaud from 2012 to 2014, and on the western 'Undertaker', that started in 2015.