Virgilio Muzzi began to draw comics in 1945, after being educated as a painter by Groppi. He illustrated several albums and covers of the publishing house Universo. Muzzi drew episodes with 'Il Cavaliere Nero' and 'Lotta nell'Ombra' for Gianluigi Bonelli in the magazine Audace. He began foreign collaborations in 1951. He drew several covers for the Brazilian Eneanto, and comics for Amalgamated Press from 1956. For Italy, Muzzi drew the 'Cagliostro' series for Dardo publishers. He became a staff artist on Bonelli's 'Tex' in 1960.