Claudio Piccoli followed art courses in Milan in 1975, before he joined the art studios of Giuseppe Montanari. He began his comics career working for Ediperiodici. He drew comics for Lanciostory and Skorpio from 1979 to 1986. He then returned to Ediperiodici, where he assisted Montanari. Piccoli drew for magazines like Tiramolla, Il Corrierino, before he began a versatile cooperation with Il Giornalino in 1994. He joined the publishing house Bonelli the same year, where he started out doing a few 'Martin Mystère' episodes. He then became an artist of the series 'Napoleone', 'Nick Raider' and 'Julia'.