Alex Robinson studied art in New York, where he graduated in 1993. Soon, he started making his own mini-comics. The first was about Bloppo, an angry clown, which appeared in three issues. In the spring of 1994, he published 'The Bohemian Girl'. Depicting life among a group of young people living in New York City, it was the first chapter in 'Box Office Poison', which became his most famous work. In 1996, Antarctic Press started publishing this series, which ended in 2000 with #21. In 2001, Top Shelf comics released 'Box Office Poison' in one 600-page book.
In 2005 Top Shelf released his next graphic novel, 'Tricked', which was nominated for an Eisner Award, and won both the 2006 Harvey Award for Best Original Graphic Novel and the 2006 Ignatz Award for Outstanding Graphic Novel. In 2007 he published the first volume of his comic series 'Lower Regions'. This was followed in 2008 by 'Too Cool to Be Forgotten', also published by Top Shelf.