Henry Scarpelli studied at the School of Visual Arts in New York City. He began his career working for a newspaper syndicate designing sales brochures and ads for feature presentations. After a while, he came up with the cartoon panel feature 'TV Tee-Hees', which appeared in 150 newspapers during the 1960s and 1970s. Later on, Scarpelli pursued a career in comic books. He first worked at Dell Publishing as the artist for TV tie-in comic books like 'The Beverly Hillbillies', 'Bewitched', 'Hogan's Heroes' and 'Get Smart'.
From there, Scarpelli moved on to major comic book publishers, such as DC, Marvel and Archie Comics. After some years of doing comic books art for Archie comics, Scarpelli was assigned to do the 'Archie' newspaper strip, both daily and Sunday in the 1990s. He remained the author of the strip with writer Craig Boldman until July 2009.