Massimo Semerano began his career in 1986, contributing to Tempi Supplementari and Frigidaire. In 1988, he created 'Doctor Cifra' in the music magazine Dolce Vita. Subsequently, he worked for magazines like Rassegna Stampa Handicap, Accaparlante, Comic Art and Mondo Mongo. In 1992-93, he contributed to the cyberpunk comic magazine Cyborg, for which he wrote 'Miracoli, Dream Master' for Giuseppe Palumbo, 'Fondazione Babele' for Marco Nizzoli and 'Europa' for Menotti. Then in 1993-96, he was present in Il Manifesto, Mano, Dinamite, Mondo Naif and Zero Zero.
In 1997, he contributed a short story to the 'Flock of Dreamers' anthology by Kitchen Sink Press. Together with Otto Gabos, he has written a story of 'Conan the Barbarian' for Marvel Italia. In 1999, he set up the project 'Frontiera - Romanzo Incompiuto in Otto Capitoli', with Otto Gabos and Omar Martini. For Black Velvet, he began the series 'Rosa di Strada'.