Rémy Simard published his first comic in a special issue of Continuum, the newspaper of the University of Montréal. He also contributed to the magazine Mic Mac with the series 'Intermède'. After obtaining his degree in political science, he illustrated several educational books in the collection Les Apprentis and cooperated on a collective comics project. He joined Jules Prud'homme's short-lived magazine Cocktail in 1982. Both Simard and Prud'homme moved on to Croc, where they cooperated on the series 'La Soeur Violente'. Simard was also present in Titanic, where he drew the police series 'Zaza Dabord'.
He succeeded Garnotte on 'Télé-Détente' in TV-Hebdo. He began the adventure series 'Ray Gliss' at the publishing house Ovale in 1984, with texts by François Benoît. For Croc-Hebdo, he drew a series of sarcastic gag strips. Simard founded the publishing house Kami-Case in 1986, where he published 'Je Sens Qu'on Me Regarde' (a collection of his work for TV-Hebdo) and 'Les Momie's', and eventually work by other authors. In 1989, Simard succeeded Pierre Fournier as the president of the ACIBD, an organization to promote Quebecois comics. In the 1990s, he began writing and illustrating children's books. He continued to do an occasional comics, such as 'Le Père Noël a une Crevaison' (1994), 'Monsieur le Président' (2000) and 'Méchant Boris' (2003).
