Cristiano Spadavecchia began his career working for some local publishers in Alessandria. He attended the Academy of Fine Arts in Turin and eventually settled in Viareggio, where he illustrated a comic book about the carnaval in Viareggio for the Fondazione Carnavale di Viareggio in 1996. Since 1999 he is working as an artist for advertisements and school books.
As a comic artist, he has worked for Sergio Bonelli Editore, Scarabeo, Piuma Blu and Orione Editore. He has illustrated volume 13 for the series '2700' and issue 4 of 'Warlords/Fantasy Warriors'. In 2001, he became the inker of Luigi Piccatto on 'Magico Vento', before becoming one of the regular artists on 'Brendon'.