Born in Brussels, Bernard Swysen began his career as the scriptwriter of the comic series 'Géraldine' (in Pourquoi-Pas?) and 'Honoré Coutille' (in Le Soir Illustré). Both were drawn by Guy Brasseur, his art school teacher. He then was an assistant to Walli & Bom ('Chlorophylle', 'Modeste & Pompon'), Bob de Moor, Jacques Martin and Peyo ('L'Aéroschtroumpf'). His first comic series was the one based on the Gaston Leroux detective 'Rouletabille', of which he made eight books with André-Paul Duchâteau for Éditions Lefrancq between 1989 and 1997. The series won a prize during the St-Nazaire Crime Festival in 1990, and was also published in Dutch and Greek. Swysen additionally worked with Duchâteau on a series of monthly crime riddles for the French magazine Télé7 Jeux.
He was present in Hello BD with 'La Châsse de St. Menas', the adventures of the young archeology professor Philippe Dythaque. The Japanese magazine Morning (Kodansha) ran his series 'Les Aventures de Capucine' during a year and his children's comic 'Noisette le Hamster' was published in Spirou and subsequently in book format by P&T Productions in 1999. Swysen had originally created the character at age 7 for his school paper, and he had self-published two comic books starring Noisette in the early 1980s. The adventures of Swysen's character 'Albert Lombaire' were pre-published in several magazines and in three books by Casterman between 2000 and 2003.
Swysen has also translated several American comic books for publication in franco-belgian newspapers. He worked with French film maker Claude Lelouch on the comics diptych 'Toute une Vie' (Soleil, 2004-05) and a comic adaptation of Lelouch's 1972 film 'L'Aventure c'est l'aventure' (Bamboo, 2010). For Bamboo, he wrote and drew the humor series 'Interim Agency' for Bamboo in 2008 and 2009, and drew 'L'Heure de la Sortie' from scripts by Adeline Blondiau during the same period. He published a comics biography of Victor Hugo with P&T Productions in 2014.
As a scriptwriter, Bernard Swysen has co-written 'Le pouvoir de convaincre' and 'Rachida - Au nom des pères' for Éditions 12bis in 2013. Both were drawn by Marco Paulo.