Enrique Villagrán, who often used the pseudonym Gómez Sierra, was one of the most prominent cartoonists for Editorial Columba. He started out as an assistant to his brother, already at the age of 16. He resumed working with his brother right after fulfilling his military service in 1963. He began his large solo production of comics in the 1970s, working with Hector German Oesterheld on features like 'Argón el Justiciero' and 'Brigada Madeleine'. He also made a series of comic adaptations of feature films, and some 'Ernie Pike' episodes for Top in 1971.
He eventually joined his brothers Carlos and Ricardo and scriptwriter Robin Wood in the Nippur IV studios. He worked for Corto Maltes and Skorpio, and worked for Columba on serials like 'Los Aventureros', 'Los Amigos' and 'Kayán'. He also drew 'Nippur de Lagash' between 1982 and 1986, and additionally created 'El señor Fonseca' for Gunga Din in 1984. Among his final creations for Columba was 'Danske, la guerrera del Futuro', a series set in a world after a nuclear holocaust in the 1990s.
His works for Columba and Record have been reprinted in Italy, and from the 1980s he also worked on US comic books like 'Superman', 'Batman', 'Robin', 'Fantastic Four', 'Punisher' and 'Conan'. In the 2000s, he continued to work on US titles like 'Fantastic Four' and 'Robin' with his brother Ricardo for Marvel and DC. He also drew 'Wicked West', 'Selena', 'Teach me' and 'Wynonna Earp', as well as European features like 'Kerry Drake' and 'Herman Storm'.