After getting his start in the comics industry in 1992 doing his own mini-comics, Andi Watson made his professional debut in 1993 with the four-issue mini-series 'Samurai Jam', published by Slave Labor Graphics/Amaze Ink. A year later, Watson created 'Skeleton Key'. His monthly 'Skeleton Key' work was followed with the mini-series 'Geisha', one of his best-received works to date.
In the same year, Watson also started writing the 'Buffy the Vampire Slayer' series for Dark Horse Comics. In 1999, Watson returned to 'Skeleton Key' with a four-issue mini-series, and he also released a trade-paperback reprinting the four-issue 'Geisha' series. In 2001, Andi Watson started the six-issue series 'Slow News Day', published by Slave Labor Graphics. Watson also made the 200-page graphic novel 'Breakfast After Noon', and the serial 'Love Fights'.