Patrick Jusseaume was born in Abidjan, Ivory Coast. After working as a drawing teacher, he turned to comics and illustrations and made his professional debut in the magazine Vécu in 1985. Working with a scenario by Daniel Bardet, Jusseame made the historical series 'La Chronique de la Maison le Quéant' for Glénat. In 1991, Jusseame created 'Trampe' with scriptwriter Jean-Charles Kraehn, a maritime series set in the 1950s, published by Dargaud.
Jusseame also made comic adaptations of the work of Andrée Chedid ('Le Sixième Jour') and Oscar Wilde ('Le Portrait de Dorian Gray') for Je Bouquine. Jusseaume illustrated the album 'L'Evangile oublié' in the series 'Le Triangle Secret' by Didier Convard. In 2003, he cooperated with Serge le Tendre and Kraehn on the album 'Mission Vietnam', published by Glénat.