After graduating from high school, Mell Lazarus became a freelance artist for various magazines. He went on to assist Al Capp on his comic 'Li'l Abner' - an experience he wrote a book about, with the catchy title 'The Boss Is Crazy, Too'. He created the kid comics 'Wee Women' and 'Li'l One' in the early 1950s, and in 1957 his popular 'Miss Peach' appeared. This comic, which he signed "Mell", was about a classroom full of rowdy kids and was an instant hit.
In 1966, under the pseudonym "Fulton", he created 'Pauline McPeril', together with artist Jack Rickard, a parody of Pearl White's 'The Perils of Pauline'. In 1970, his strip 'Momma' appeared. Mel Lazarus received several awards from the National Cartoonists Society, of which he was president from 1989 until 1993. Mel Lazarus is also the author of several novels, theatre productions and TV adaptations.