Franco Lostaffa illustrated some coloring books for the publishing house Carroccio in the late 1940s. He was then assigned by the publisher Caregaro (Alpe) to draw 'I Bandisti di Brema' in Cucciolo. He briefly cooperated on Mimoso, before he joined the publishing house Mondadori in 1954. He started out as a letterer, and became an editor of the Disney magazine Topolino. He drew his first comics with Disney characters in 1964. He initially worked together with artist Adriana Cristina, but eventually got a production of his own until 1982. Between 1976 and 1982, he drew all the stories that appeared in Il Club Delle Giovani Marmotte (Junior Woodchucks magazine). He returned to Topolino's editorial office in 1983, and stayed there until 1988, when he became an artist of the international Disney Studios.