Born in Genoa, Ernesto Piccardo studied fine arts in 1947, and began his career in the advertising and cinema fields between 1948 and 1952. From 1952, he worked for various publishers, such as Alpe ('Canafora', 'Marcello e Gianni'), Mondadori, Il Ponte, Alba d'Oro and Arti Grafiche Stringa. In 1954, he drew for the humorous pages of the review Rosso e Nero. Comics became his main focus in 1956.
For publisher Bianconi, Piccardo inked Giovan Battista Carpi's 'Nonna Abelarda' stories until 1963, and he drew comics like 'Odino' and 'Joe Belote'. Piccardo additionally inked a couple of Carpi's Disney comics for Topolino. For the same publisher (Mondadori), he illustrated the 1958 book of 'Biancaneve e i Sette Nani'.
Signing E. Picca or E. Picc, Piccardo has also created several comics on his own, such as 'Billy' in Lo Scolaro, as well as 'Cariolò' and 'Pin Robot & Prof. Cosmik' for Oscar in 1961. His best known creation is most likely 'Ulisse', published by publisher Fasani between 1954 and 1965. His work was also translated for several French pockets books of the 1950s and 1960s, such as Artima's Zéphyr and Bravo ('Pin Roby'), Pim Pam Poum ('Pic et Pac), Bimbo ('Odino'), Pépito ('Ulysse') and publications of Lug publishers ('Belcorne'). Piccardo is also a painter.