Together with his writing companion Charles Berberian, Philippe Dupuy is considered one of the leading present-day comics authors. Dupuy made his debut in 1980 with the comic 'Le Père Gaston' in Aïe magazine. In the following three years, Dupuy worked for various fanzines until he met Charles Berberian. Two kindred souls recognized each other and decided to join their talents from that time on.
Together, they have worked on several projects, each cooperating on both scenario and artwork. Dupuy and Berberian began their collaboration with an homage to Hergé in Band' à Part and in P.L.G.P.P.U.R. These first efforts for the latter were collected in the album 'Les Héros ne Meurent Jamais' by L'Association in 1991. They then joined Fluide Glacial magazine, for which they created 'Red, Basile et Gégé' and most notably, 'Le Journal d'Henriette', the diary of a timid young adolescent girl. This series, which was later retitled to simply 'Henriette', was continued in Je Bouquine from 1995 and in Spirou from 2003.
In 1985, the duo published 'Le Petit Peintre' at Magic Strip, followed by the 'Chantal Thomas' portfolio, published by Michel Lagarde in 1987. Their work also appeared in the magazines of the juvenile press, such as Mikado, Fripounet and I Love English.
But their biggest claim to fame is the 'Monsieur Jean' series, in which they explore the humor of everyday life. 'Monsieur Jean' premiered in the Frank Margerin Présente anthologies in 1989, and was soon afterwards continued in the Yéti review. Book collections were published by Les Humanoïdes Associés and Dupuis. In 1997, Dupuy and Berberian made 'Le Monde est Fou', based on a script by Vincent Ravalec, for À Suivre. The 'M. Jean' comics portray a generation in a gentle, yet gripping way. As proof of the success of the books, Dupuy-Berbérian won the prestigious Angoulême Alph-Art Award for the Best Book of the Year 1999 for 'Monsieur Jean 4: Vivons heureux sans avoir l'air'.
Together with Berberian and 18 other comic artists (Zep, Ptiluc, Frank Margerin, Yslaire, Cosey, Philippe Vuillemin, Milo Manara, Loustal, Gilbert Shelton, Max Cabanes, François Boucq, Gérald Poussin, Thomas Ott, Frank Pé, Frank Le Gall, Riff Reb's, Eric Buche, Enrico Marini and Valott) he illustrated a record single for the project '20 Vraies Fausses Pochettes De Disque Par 20 Vrais Dessinateurs de BD' (1995). They chose for a song by Juliette Gréco.
In addition to their careers as comics authors, Dupuy and Berberian are also active in the illustration field. They work for the advertising field (Canal +, Les Vins Nicolas), the press (Libération, The New Yorker) and publishing field. Throughout the years, they have also published several portfolios and illustrated books, such as their series about cities that were an inspiration to them, published by Cornélius. In 1998, they became creative directors of the collection Tohu Bohu at Les Humanoïdes Associés, in which they published the 'Monsieur Jean' spin-off 'La Théorie des Gens Seuls'.