Román Arámbula has mainly worked in animation, but he also had some stints in the field of comics. He did cartoons and illustrations for Mexican magazines, and started out with working for television commercials in the 1960s. He then became a layout artist on Hanna-Barbera cartoons like 'Josie and the Pussycats', 'The Hair Bunch' and 'Wheelie and the Chopper Bunch' in the first half of the 1970s.
Arambula did his first comics for the Disney Studios in the early 1970s. After doing some 'Mickey Mouse' strories for the production for foreign comic books he took over the daily 'Mickey' strip from Floyd Gottfredson in 1975. He drew the strip until 1989, and from 1984, he also drew the Sunday page. He has additionally done some art for Hanna-Barbera's 'Laff-a-Lympics' and 'Undercover Elephant' comic stories in the late 1970s.
He returned to animation in the 1990s, working as an assistant director on 'The Oz Kids' by Hyperion Pictures. He also worked as a storyboard artist for Marvel ('Little Shop of Horrors') and Warner Bros ('Pinky and the Brain').