Serge Carrère studied plastic arts in Aix-en-Provence, before he started out working in the advertising field. He turned to making comics in 1980, starting with some stories for Tintin and several fanzines. From 1983, he stated producing work for the magazine Mikado and the publishing house Milan. This included the series 'Coline Maillard' with Patrick Cothias, as well as the more realistic 'Rémi Forget' with Alain Oriol.
In addition, he made 'Smok le Clown' with Gérard Moncomle in Fripounet (1986-88) and some short stories scripted by René Durand for Circus. He also continued the series 'Les Tristus et les Rigolus' in Pif for two episodes, and appeared in Spirou with 'S.O.S. Veto'. In 1992, Carrère teamed up with scenarist Scotch Arleston and created his most famous series, 'Léo Loden', for Soleil Productions. The series runs until today, and from 2006, the duo have assistance from Loïc Nicoloff for the scripts.
Also from 1992, Carrère has made several comic adaptations of stories by De La Fontaine with scriptwriter Dugomier for Fripounet. Between 2001 and 2003, while continuing to work on 'Léo Loden', he took on a more semi-realistic style and created 'Private Ghost' with Crisse, also for Soleil.
He is also active as a scriptwriter for others, regularly in cooperation with Weissengel. Carrère has (co-)created such series as 'Cerbères' (art by Serge Fino, Soleil, 2008), 'Les Elfées' (art by Dollphane, Dupuis, since 2008), 'Les Quatre Quarts' (with art by Simon Léturgie and Soffritti, 12 bis, 2010-2011) and L'École Crinoline' (art by Grégory Saint-Félix, Bayard, 2012-2013).
Carrère and Weissengel have additionally created the sci-fi comic 'L'Héritier des Étoiles' for Vents d'Ouest (2006-2008), for which Carrère provided the artwork himself. Since 2010, Carrère is also present at Éditions Bamboo with 'Les Scientiflics', a humorous series written by Jean-Louis Janssens.