Jacques de Loustal is one of the most popular French contemporary artists, and his influences lean more towards fine art than to comics. Loustal has been in Africa for a good part of his life, which is strongly reflected in his comics. While still studying architecture, he cooperated on the fanzine Cyclone, which was published by his college in Sèvres. After cooperating on among others Rock & Folk, he started making some short comic stories for Métal Hurlant, Pilote, Nitro, Chic, Zoulou and Libération, mostly in cooperation with writer Philippe Paringaux. Some of his work for Métal Hurlant has been published in albums by Humanoïdes Associés, like 'New York', 'Miami' and 'Clichés d'Amour'.
From 1984 Loustal became a frequent contributor to the monthly À Suivre, for which he created 'Coeurs de Sable', 'Barney et la Note Bleue', 'Un Jeune Homme Romantique' and 'Kid Congo'. In addition, his work was present in L'Écho des Savanes with several short stories. Throughout the 1980s and 1990s, numerous album collections appeared, to name a few: 'Zenata-Plage', 'Pension Maubeuge', 'V comme Engenance', 'Le Prince et Martin Moka', '19 Pastels' and 'Dune'. In 1999, he made 'Insolite' for Le Seuil and in the following year, he produced 'White Sonya' with scriptwriter Charyn for Casterman. With the same publisher, he subsequently worked on a series of albums with Jean-Luc Coatalem ('Jolie Mer de Chine' and 'Rien de Neuf à Fort-Bongo'.
Together with 20 other comic artists (Zep, Ptiluc, Frank Margerin, Yslaire, Cosey, Philippe Vuillemin, Milo Manara, Gilbert Shelton, Max Cabanes, Dupuy & Berberian, François Boucq, Gérald Poussin, Thomas Ott, Frank Pé, Frank Le Gall, Riff Reb's, Eric Buche, Enrico Marini and Valott) he illustrated a record single for the project '20 Vraies Fausses Pochettes De Disque Par 20 Vrais Dessinateurs de BD' (1995). Loustal chose for a song by Charlélie Couture.
Besides comics, Loustal has had an extensive career in illustration. He has contributed to several publications and produced various portfolios for among others Magic-Strip, Alain Beaulet, L'Atelier, Carton and Les Humanoïdes Associés.