Georges Colomb was a professor of natural science and sub-director of the botanical institute in Sorbonne when he first published his drawings in Mon Journal, in 1887. He used the pseudonym Chistophe (referring to Christopher Columbus). Two years later, he created 'La Famille Cornouillet' for the magazine Journal de la Jeunesse. This family was a prototype for 'La Famille Fenouillard', which appeared in Le Petit Français Illustré from 1889 until 1893.
He continued to draw comics for this magazine until 1899. In 1915, his 'Les Douze Commandments de Lord Curzon' was published by editor Armand Collin. A lot of his work has been reprinted after his death in 1945. In 1975, his granddaugher Hélène Colomb dedicated the book 'Mon Grand-père Christophe' to him.